Neuronal adhesion, morphology and function

We are currently investigating the role of integrins, focal adhesion complexes, and associated signaling in the cytoskeletal filaments in cellular differentiation, synapse formation and electrical signaling. The impact of different extra-cellular matrix properties (such as nano-scale topographical features and different protein identities and their concentrations) on neuronal morphology and function is carefully assessed using novel micro- and nano-technologies developed in our lab. Using in vitro primary neuronal culture models, we hope to understand the mechanisms of structural and functional plasticity.

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Genes and neural circuits

We are interested in understanding the causal role of specific genes and proteins on single neuronal and neuronal circuit function. Using genetically defined cell types and novel targeted gene/RNAi delivery technologies developed in our lab, we are assessing the role of specific synaptic and cytoskeletal signaling proteins in determining the synaptic structure and function.

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