Interactive AcrA molecule; Mutation Analyzer

 

 

Click on the buttons below to view where the mutation

maps in the hypothetical crystal structure of AcrA.

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the molecule may take a few moments to load. Please be patient.

 

The crystal structure of MexA is presented, an AcrA homologue from Pseudomonas aeruginosa.  Higgins, M. K.Bokma, E.Koronakis, E.Hughes, C.Koronakis, V.: The Structure of the Periplasmic Component of a Drug Efflux Pump To be Published.  AcrA has yet to be crystallized. Residues highlighted are the homologous residues present in MexA to mutations isolated in AcrA. 

 

The TolC crystal structure is available from the protein databank. (http://www.rcsb.org)
The Plug-in CHIME is available from MDL. (http://www.mdl.com/chime/)
 

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page last updated January 26, 2003