Publications

Refereed papers

Frandsen, J., Gunn, B. & Newfeld, S.J. (2008) Salmonella pathogenesis reveals that BMP signaling regulates proliferation and differentiation in the hematopoietic stem cell niche of Drosophila. (submitted)

Takaesu, N.T, Bulanin, D., Orenic, T. & Newfeld, S.J. (2008) A combinatorial enhancer recognized by Mad, TCF and Brinker first activates then represses dpp expression in the posterior spiracles of Drosophila. Dev. Biol. (in press, January 15).

Drosophila Comparative Genome Sequencing and Analysis Consortium (2007) Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203-218.

Hudson, S.G., Garrett, M., Carlson, J., Micklem, G., Celniker, S., Goldstein, E.S. & Newfeld, S.J. (2007) Phylogenetic and genome-wide analyses suggest a functional relationship between kayak the Drosophila Fos homolog and fig a predicted PP2C phosphatase nested within a kayak intron. Genetics (177:1349-1361).

Johnson, A.N., Burnett, L., Sellin, J. Paululat, A. & Newfeld, S.J. (2007) Defective Dpp signaling results in heart overgrowth and reduced cardiac output in Drosophila. Genetics 176:1609-1624

Takaesu, N.T., Hyman-Walsh, C.A., Ye, S., Wisotzkey, R.G., Stinchfield, M.J., O'Connor, M.B., Wotton, D.& Newfeld, S.J.(2006) dSno facilitates Baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics (174:1299-1313).

Newfeld, S. J. & Wisotzkey, R.G. (2006) Molecular Evolution of Smad Proteins. In Smad Signal Transduction, Eds. C. Heldin, & P. ten Dijke, Springer, Netherlands, pp. 15-35.
-- Invited Chapter One and the Cover Illustration for the first book on the Smad Family.

Takaesu, N.T., Herbig, E.J., Zhitomersky, D., O'Connor, M.B. & Newfeld, S.J. (2005) DNA-binding domain mutations in Smad genes yield dominant negative proteins or a neomorphic protein that can activate Wg target genes in Drosophila. Development 132:4883-4894.

Hyman, C.A., Bartholin, B., Newfeld, S.J. & Wotton, D. (2003) Drosophila TGIF proteins are transcriptional activators. Molecular and Cellular Biology 23:9262-9274.

Johnson, A.N. Bergman, C., Kreitman, M. & Newfeld, S.J. (2003) Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells. Developmental Biology 262:137-151.

Wisotzkey, R., Johnson, A., Takaesu, N.T. & Newfeld, S.J. (2003) α / β hydrolase2, a predicted gene adjacent to Mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity. Journal of Molecular Evolution 56:351-361.

Kumar, S., Jayaraman, K., Panchanathan, S., Gurunathan, R., Marti-Subirana, A., & Newfeld, S.J. (2002) BEST: A novel computational approach for comparing gene expression patterns from early stages of Drosophila melanogaster development. Genetics 162:2037-2047.

Takaesu, N.T., Johnson, A.N. & Newfeld, S.J. (2002) Posterior spiracle specific GAL4 lines: New reagents for developmental biology and respiratory physiology. genesis: the Journal of Genetics and Development 34:16-18.

Takaesu, N.T., Johnson, A.N., Sultani, O. & Newfeld, S.J. (2002) Combinatorial signaling by an unconventional Wg pathway and the Dpp pathway requires Nejire (CBP/p300) to regulate dpp expression in posterior tracheal branches. Developmental Biology 247:225-236.

Newfeld, S.J. & Takaesu, N.T. (2002) An analysis using the hobo genetic system reveals that combinatorial signaling by the Dpp and Wg pathways regulates dpp expression in leading edge cells of the dorsal ectoderm in Drosophila. Genetics 161:685-692

Johnson, A.N. & Newfeld, S.J. (2002) The TGF-β family: Signaling pathways, developmental roles and tumor suppressor activities. The Scientific World Journal 2:892-925. Invited research review (Editor - Norbert Perrimon, Harvard Medical School).

Marquez, R.M., Singer, M.A., Takaesu, N.T., Waldrip, W.R., Kraytsberg, Y. & Newfeld, S.J. (2001) Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157:1639 -1648.

Su, M.A., Wisotzkey, R.G. & Newfeld, S.J. (2001) A screen for modifiers of dpp mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt’s Lymphoma family of transcription factors in Drosophila melanogaster. Genetics 157:717-725.

Jockush, E., Nulsen, C., Newfeld, S.J. & Nagy, L. (2000) Leg development in flies versus grasshoppers: Differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway. Development 127:1617-1626.

Newfeld, S.J., Wisotzkey, R.G. & Kumar, S. (1999) Molecular evolution of a developmental pathway: Phylogenetic analyses of TGF-β family ligands, receptors and Smad signal transducers. Genetics 152:783-795.

Newfeld, S.J. & Takaesu, N.T. (1999) Local transposition of a hobo element within the decapentaplegic locus of Drosophila. Genetics 151:177-187.

Newfeld, S.J., Mehra, A., Singer, M.A., Wrana, J.L., Attisano, L. & Gelbart, W.M. (1997) Mothers against dpp participates in a dpp/TGF-β responsive serine-threonine kinase signal transduction cascade. Development 124:3167-3176.

Newfeld, S.J., Padgett, R.W., Findley, S.D., Richter, B.G., Sanicola, M., de Cuevas, M. & Gelbart, W.M. (1997) Molecular evolution at the decapentaplegic locus in Drosophila. Genetics 145:297-309.

Newfeld, S.J., Chartoff, E.H., Graff, J.M., Melton, D.A. & Gelbart, W.M. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in dpp/TGF-β responsive cells. Development 122:2099-2108.

Schmid, A., Newfeld, S.J. & Yedvobnick, B. (1996) Interspecific RNA in situ hybridization reveals perinuclear mastermind transcripts in Drosophila virilis. Molecular Biology & Evolution 13:280-282.

Sekelsky, J.J., Newfeld, S.J., Raftery, L.A., Chartoff, E.H. & Gelbart, W.M. (1995) Genetic characterization and cloning of Mothers against dpp: A gene required for decapentaplegic function in Drosophila. Genetics 139:1347-1358.

Newfeld, S.J. & Gelbart, W. (1995) Identification of two Drosophila TGF-β family members in the grasshopper Schistocerca americana. Journal of Molecular Evolution 141:155-160.

Brummel, T., Twombly, V., Marques, G., Wrana, J., Newfeld, S.J., Attisano, L., Massagué, J., O'Connor, M. & Gelbart, W.M. (1994) Characterization and relationship of dpp receptors encoded by the Sax and Tkv genes in Drosophila. Cell 78:251-262.

Newfeld, S.J., Tachida, H. & Yedvobnick, B. (1994) Drive-selection equilibrium: Homopolymer evolution in Drosophila gene mastermind. Journal of Molecular Evolution 38:637-641.

Newfeld, S.J., Schmid, A.T. & Yedvobnick, B. (1993) Homopolymer length variation in the Drosophila gene mastermind. Journal of Molecular Evolution 37:483-495.

Takaesu, N.T., Newfeld, S.J. & Hassold, T.J. (1992) Characterization of three VNTR systems at D21S112. Genomics 14:816-817.

Newfeld, S.J., Smoller, D. & Yedvobnick, B. (1991) Interspecific comparison of the unusually repetitive Drosophila locus mastermind. Journal of Molecular Evolution 32:415-420.

Non-refereed papers

Kumar, S. & Newfeld, S.J. (2002) Review of Modern Genetic Analysis by Griffiths, Gelbart, Lewontin & Miller. Quarterly Review of Biology 77:456-457. Invited textbook review.

Waldrip, W.R., Takaesu, N.T. & Newfeld, S.J. (2001) Identification of blue balancers and mutant collections compatible with hobo element transgenes. Drosophila Information Service 84:169-172. Technical note.