RESOURCES: Microscopy

• W.M. Keck Bioimaging Resource: (LSC Building)

  This facility, made possible by the W.M. Keck Foundation, 
  contains state-of-the-art: 1) Scanning laser confocal microscopy;
   2) Multi-photon confocal microscopy; 3) Scanning probe 
  microscopy; 4) Ratio Imaging Microscopy; and 5) Video/time 
  lapse Microscopy.  In addition, this research core contains microinjection apparati capable of injecting single cells, a PhosphorImager^TM, protein and DNA computer modeling 
  software, and several off-line analysis systems. This resource 
  is available to users in academia and industry.  http://lsvl.la.asu.edu/Klab/text/equipment.html   

The BME core imaging facility in 730 ft² of contiguous space houses an inverted microscope (Leica DM IRBE) with fluorescence, phase contrast, and modulation contrast capabilities and micropippetor/micromanipulator system. This scope has a color digital video camera (Optronics 750D) for fluorescence and bright field image acquisition and analysis. This facility has an upright research microscope (Leica Axioplan) with fluorescence, brightfield, and phase contrast capabilities with digital (Optronics Magnafire) and photo imaging capabilities (Leica photo system), and computers for digital image processing. This facility has a stereomicroscope (Leica MZFLIII) with brightfied and fluorescence capabilities with a video port for digital imaging.  All computers are connected to the university network server. This facility has a high resolution color laser printer (Tektronix Phaser 850) for publication quality hard copies of digital images. The Core Bioengineering Facilities also house a goniometer with computer imaging capabilities (Rame Hart, Inc., Mountain Lakes, NJ) for surface analysis by contact angle measurements. http://www.eas.asu.edu/~bme/ (Click on facilities).

• Biological and Cryo Electron Microscopy: (LSC Building)

This biological electron microscopy resource contains multiple electron microscopes and uniquely serves the SouthWest in cryoelectron microscopy.   The resource contains one of the few high pressure freezers in the SouthWest used for ultra-rapid freezing, as well as other ultra-rapid freezing technologies including cold metal block freezers.  A freeze fracture device (capable of deep-etching biological material) and ultracryotomes are also available to users in the University as well as in industry.  http://lsvl.la.asu.edu/lsem/

• Cell Biotechnology Laboratory: (LSA Building)

This resource is available principally to students and faculty at Arizona State University.  Industrial users can approach the “Mammal Cell Culture Resource” described above.  This laboratory was made possible by grants from the Howard Hughes Foundation (in support of undergraduate research) and the Whitaker Foundation (Program Development Award).  The laboratory’s principal function is to create an environment to jointly train advanced undergraduate students and beginning graduate students from both the Life Science and Bioengineering Departments in a formal course setting where the students can learn the paradigms, vocabulary, and limitations of each discipline, as well as promoting team work.  Students gain experience in mammalian cell culture, the growth of mouse embryonic stem cells, the use of microgravity bioreactors and microcapillary bioreactors, and a variety of other techniques in cell biology.  This laboratory is in use year round by students.  http://lsvl.la.asu.edu/bio494/dcapco/  and http://www.eas.asu.edu/~bme/ (click on facilities)

• High Resolution Electron Microscopy Center: (PSC Building)

The Center for High Resolution Electron Microscopy (CHREM) is a facility that operates a number of ultrahigh resolution and ultrahigh vacuum electron microscopes for external and internal user groups. It also maintains a vigorous program of microscopy methods and instrumentation development including holography, position and time resolved nanospectroscopy, both dynamic and static controlled‑atmosphere TEM and energy filtered imaging and diffraction. Latest developments, including applications to interdisciplinary materials research and instrumentation, are communicated to the technical community during annual high resolution electron microscopy schools, at topical interdisciplinary research workshops, and at users meetings held at national technical meetings of societies, such as the Microscopy Society of America and the Materials Research Society.  http://www.asu.edu/clas/chemistry/HREM.htm

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